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Pipeline Glance:

Click on a target to access more info of each.  Classes of targets include oncology, infectious disease, autoimmunity, and inflammation.  This is an ever changing list that mostly includes antibodies generated in the first 2-3 years of North Coast’s existence and they have been posted for outlicense since last Nov., thus statuses have changed for some of these hits. 

We fund North Coast with out-licensing.  We like to do the discovery and in vitro POC where possible and then we out-license to companies that are competent in developing antibodies through to approval. 


We will also partner discovery to give collaborators a chance to select their antibody of choice.  Unlike other technologies, BLAST gives you access to virtually all of mother nature’s diversity in variable regions.  The antibody you would prefer to develop is often never screened via other technologies due to various inefficiencies.  So rather than thinking of antibodies the way we use small molecule libraries (ie. get a few hits and do med chem until you get close to what you really want), we let you actually select your drug right up front without affinity maturation and sometimes even without humanization. 

Out-license for Product Development

Products/Entries/2012/11/28_Human-derived_antibodies_for_outlicense.html
Products/Entries/2012/11/28_Orai-1__Functional_rabbit_antibody_made_fully_human.html
Products/Entries/2012/11/29_Anti-sclerostin_fully_human_neutralizing_antibody.html
Products/Entries/2012/11/29_CD40_agonist_and_antagonist_therapeutic_antibodies_%7BAntagonist_is_sold%7D.html
Products/Entries/2012/12/5_7TM_receptor_antibodies_for_outlicense.html
Products/Entries/2012/12/6_Neutralizing_human_mabs_to_IL-6_and_NGF.html
Products/Entries/2012/12/10_Fully_human_antibodies_to_CD37,_CXCR3,_CD19,_CD20,_CD63_%26_more.html
Products/Entries/2012/12/6_Neutralizing_human_mabs_to_IL-6_and_NGF.html
Products/Entries/2012/12/20_Diabetes__Humanized_Anti-idiotype_to_auGAD65,_Insulin-R_agonist,_GIP1R_agonist.html
Products/Entries/2012/12/25_PD-1_%26_CTLA4_functional_human_antibody_therapeutics_-_Merry_Christmas%21.html
Products/Entries/2013/1/7_Fully_human,_IL-17___IL-22_neutralizing_antibodies.....html
Products/Entries/2013/1/16_PCSK9_humanized_antibody_inhibitor__A_validated_target_for_hypercholesterolemia.html
Products/Entries/2013/1/25_CGRP__humanized_ultra_high_affinity_inhibitory_antibody.html
Products/Entries/2013/3/30_Anti-T-cell_antibodies__high_affinity_mabs_to_CD3,_CD4,_CD8,_CD25_and_more....html
Products/Entries/2013/4/2_CRTH2__Back_by_popular_demand..._Reserve_your_spot_for_CRTH2_part_2..html
Products/Entries/2013/4/3_More_7TM_therapeutics__anti-GPR40_%26_anti-GPR119_therapeutic_antibodies.html
Products/Entries/2013/5/16_CD55_splice_variant-specific_humanized_monoclonal_antibodies_4-sale.....html
Products/Entries/2013/8/5_Discovery-stage_antibodies_specific_for_fetal_nucleated_RBCs_%28fnrbcs%29__1200_to_be_exact....html
Therapeutic Antibodies